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How Tirzepatide Works Tirzepatide (the active ingredient in Mounjaro) is a dual agonist. It mimics two hormones: GLP-1 and GIP (glucose-dependent insulinotropic polypeptide)

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Several gut microbiota species, called the obesogenic gut microbiota, can significantly contribute to obesity, such as Firmicutes, Bacteroidetes , Rhizobium, Lactococcus , and Clostridium ( Some mechanisms have been proposed to define the role of gut microbiota in the development of obesity

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When the animals are placed on a calorie-restricted diet they lose the excess fat and leptin levels decline